IL10 and lymphoproliferative syndrome: Among them, IL-10, an immunosuppressive cytokine contributing to viral persistence in and pathogenesis of KSHV-associated lymphoproliferative disorders (33, –, 35), showed a consistent induction by KSHV reactivation (>1.5-fold) in KDM4A-WT-, but not in KDM4A-K471R-expressing cells (Fig. 4A).