CD44 and cancer: The SKBR3 cell-membrane landscape of oncogenes, tumor suppressors and existing drug targets revealed one such example of a group of key receptors (EGFR, ERBB, FGFR, IGFR, MET, MTOR, MAPK/RAS proteins), CD antigens (CD274, CD44), adhesion proteins (EPCAM, MUC1), and ABC transporters (ABCC1/2/3) that have been already explored for effective targeting of various cancers (Fig 3A).