Through PPI networks, attention can be expanded to a vast set of membrane proteins that when targeted in a combinatorial or sequential fashion can impair cancer proliferation and dissemination not only through well-established mechanisms such as RAS/ERK or PI3K/AKT signaling, but also via processes implicated in angiogenesis, migration, cell death, metabolic reprogramming, inflammation, or remodeling of the tumor microenvironment. This evidence concerns the gene AKT1 and cancer.