INS and Insulin resistance: It is likely due to the time-consuming and expensiveness of the gold standard method of IR assessment, Hyperinsulinaemic-euglycaemic clamp technique [15], and also, lacking standardization, availability, and cost-effective of the insulin assessment method for indirect estimation of IR such as homeostasis model assessment for insulin resistance (HOMA-IR), the fasting glucose to insulin ratio (FG-IR), and the quantitative insulin sensitivity check index (QUICKI) [16].