TSPAN3 and hepatocellular carcinoma: The inflammatory pathway interferes with mature miR-197-3p biosynthesis [30] in the HCC cell model through increased SERPINA3 levels that were associated to the acute and chronic inflammation [31]; it has been hypothesized that over-expression of miR-21-3p and down-expression of miR-197-3p targeting L1CAM, SERPINA3 and TSPAN3, respectively, could induce or maintain the inflammatory process in mutated DT, although the physiological function of the SERPINA3 protein in sporadic DT is unknown [15].