APC and desmoid tumor: Although CTNNB1 and APC mutations are mutually exclusive, they affect the same endpoint, the Wnt/ β-catenin pathway[3] suggesting a near universal relationship between desmoid tumors and Wnt signaling [4]: with deep sequencing 95% of desmoids may be found that have mutations affecting the Wnt/APC/β-catenin signaling pathway, and whole-exome sequencing and genomic analysis identified no other recurrent alteration [36, 19, 37, 10].