Risk for PARDS in a cohort of intubated children with sepsis was associated with TNFA-863 C>A genotype (rs18000630), and the TNFA-308 G>A genotype (rs1800629) had a protective effect against mortality in sepsis-associated PARDS (Azevedo et al., 2012). This evidence concerns the gene TNF and pediatric acute respiratory distress syndrome.