In adults with sepsis, ANGPT2 intronic SNPs (rs2442608 and rs2442630) have been associated with increased susceptibility to acute lung injury (ALI) (Meyer et al., 2011) or ARDS across multiple cohorts (Su et al., 2009), one in which plasma ANGPT2 was implicated as a causal intermediate (Reilly et al., 2018). Here, ANGPT2 is linked to acute lung injury.