Nephrectomy has been shown to temporarily ameliorate hypercalcemia in a subgroup of patients with metastatic renal cancer and hypercalcemia in a study by Walther et al. In their study, a decrease in serum calcium corrected for albumin occurred in 9 of 11 patients at 1 to 4 weeks after nephrectomy and in 7 of 12 patients at 5 to 16 weeks after nephrectomy.17 However, with the emergence of targeted therapy for advanced RCC, the role of cytoreductive nephrectomy has become a debated topic. This evidence concerns the gene ALB and Hypercalcemia.