Most of those hits aligned CBU1639 with the nucleotide binding adaptor shared by APAF-1, certain R gene products, and CED-4 (NB-ARC) domains of proteins involved in the host response to infection, including the apoptosomes of Drosophilamelanogaster, Homosapiens, and Caenorhabditiselegans, as well as Arabidopsis thaliana resistance proteins and the murine NAIP5-NLRC4 inflammasome (see Fig. S1 in the supplemental material). The gene discussed is NLRC4; the disease is infection.