This makes pathophysiologic sense in acute COVID-19, as male sex at birth is linked to elevated basal levels of those proinflammatory cytokines (IL-6, CRP), coagulation factors, and complement components implicated in the hypercoagulable and proinflammatory state of acute SARS-CoV-2 infection (63–65) (Figure 1B). This evidence concerns the gene CRP and COVID-19.