IGHE and Alzheimer disease: Without causing activation of human basophils (Figure 1A), UB-221 can inhibit the IgE-OVA–induced degranulation in RBL SX-38 basophils (Figure 1B), potently reduce high IgE in sera of patients with AD ex vivo (Figure 7), and can induce rapid, pronounced reduction in serum IgE in hIGHE-knockin mice (Figure 8, E and F).