Supporting the brain-homing properties of CXCR3/CXCL10 for CD8+ TRLs after stroke, CD8+ TRLs failed to infiltrate ischemic brain in Cxcl10-KO (Figure 3, D and E) and Cxcr3-KO (Figure 3, D and F) mice. The gene discussed is CD8A; the disease is stroke disorder.