To determine whether the therapeutic potential of CD8+ TRLs is relevant to different stroke populations in the clinic, we evaluated the therapeutic effect of CD8+ TRLs in aged mice using the model of distal middle cerebral artery occlusion (dMCAO) (Supplemental Figure 7E), which mimics the clinical condition of ischemic stroke patients who are unqualified for recanalization therapy. The gene discussed is CD8A; the disease is ischemic stroke.