Giavridis et al. genetically engineered T cells to simultaneously express anti-CD19 CAR and IL-1 receptor antagonist (IL-1Ra), anakinra.71 IL-1 is known as one of the crucial cytokines in worsening CRS,70,71 and systemic administration of anakinra successfully abrogated CRS-related mortality in a mouse model of CRS in their study. This evidence concerns the gene CD19 and congenital rubella syndrome.