CD19 and Burkitt lymphoma: CD19+ human Burkitt's lymphoma-bearing immunodeficient mice (retaining macrophages) treated with both MTR and anti-CD19 CAR-T cells (hCART19) had augmented survival rates and significantly lower levels of catecholamines and inflammatory cytokines, compared to mice treated with CAR-T cells only.72 Similarly, the combined use of either ANP or MTR with CAR-T cells reduced the systemic release of catecholamines and inflammatory cytokines while retaining the therapeutic efficacy of CAR-T cells in a syngeneic mouse leukemia model.