The scFv binds to the TAA, thus initiating the CAR-T cell's response, independent of the major histocompatibility complex (MHC); this property presents CARs with an advantage over T cell receptors (TCRs), which are MHC-dependent and prone to tumor cells’ actions to evade detection, such as MHC downregulation.6,7 The scFv is connected by a hinge through the transmembrane domain. This evidence concerns the gene HLA-C and neoplasm.