However, animal model studies showed some potential mechanisms which consist of (a) improvement of hepatic insulin sensitivity (Matsuura et al., 2004) via enhanced fatty acid oxidation, and decreased lipogenesis (Kuda et al., 2009; Wu et al., 2012), (b) insulin‐sensitizing effect by increased release of adipocytokines such as adiponectin and leptin (Rossi et al., 2005), and (c) prevention of insulin‐resistance via direct (D. Y. Oh et al., 2010) and indirect (González‐Périz et al., 2009; Serhan, Chiang, & Van Dyke, 2008) antiinflammatory effects. This evidence concerns the gene INS and Insulin resistance.