Similarly, to the Anderson et al. (1999), Ziai et al. (2005) showed that the assumption of 10.2 g/day of psyllium 20–30 min before breakfast and dinner for 8 weeks in 49 T2DM patients determined a significant reduction of FPG (−28.00 mg/dl, −60.60%, p < .05) and HbA1c levels (−1.60%, −15.20%, p < .05) without any change of insulin values by comparison to placebo (Ziai et al., 2005). Here, INS is linked to type 2 diabetes mellitus.