The historically uncommon association of EBV with plasma cell neoplasms, as opposed to some other B-cell lymphomas, is primarily ascribed to the absence of the EBV receptor CD21 on plasma cells.12, 37, 38 The tumorigenesis of plasma cell neoplasms is still incompletely understood, as myeloma cells are notoriously difficult to culture. This evidence concerns the gene CR2 and B-cell non-Hodgkin lymphoma.