Traditionally, p53-induced apoptosis was considered a main mechanism that inhibited tumor development by regulating downstream target genes. At present, numerous P53 target genes are involved in apoptosis regulation, which can be mainly divided into two categories: death receptor family and the bcl-2 family. Numerous studies have shown that lncRNAs regulated the expression and degradation of p53 through a variety of downstream molecules, thus affecting the glioma cell apoptosis. This evidence concerns the gene TP53 and central nervous system cancer.