CDKN1A and glioma: For example, a study (20) comparing 108 glioma to control tissue samples found that lncRNA SNHG20 was highly expressed in glioma tissue and negatively correlated with patient prognosis. Further study of the specific mechanism showed that lncRNA SNHG20 accelerated the G0/G1 cycle by reducing p21 transcription, ultimately leading to the glioma cell proliferation.