observed that miR-122-enriched exosomes, obtained from adipose tissue-derived mesenchymal stem cells (AMSC) after transfection with miR-122 expression plasmids, inhibited HCC cell proliferation and increased sensitivity to 5-FU and sorafenib both in vitro and in xenograft mouse models, by targeting and downregulating the expression of CCNG1, ADAM10 and IGF1R, genes involved in tumorigenesis and drug sensitivity in several cancer types. The gene discussed is ADAM10; the disease is hepatocellular carcinoma.