Several pathways, such TGF-β, Wnt/β-catenin, Hedgehog, Notch, EGF, HGF, VEFG, JAK/STAT, Hippo, and HIF are dysregulated and play a crucial role in HCC, leading to uncontrolled cell division and metastasis. Here, TGFB1 is linked to hepatocellular carcinoma.