In addition, increased adipocyte infiltration in the pancreas and hypertrophy of peritumor adipocytes, and increased levels of tumor tissue LDs formation-related proteins Mannose-6-phosphate receptor binding protein 1 (TIP-47) and Adipose differentiation-related protein (ADRP) were also found in EL-KrasG12D/PEDF deficient mice (120). This evidence concerns the gene PLIN2 and neoplasm.