CXCL1 and neoplasm: In addition, inflammatory mediators produced in areas of chronic inflammation, prostaglandins, interleukin 1 beta, TNF-α, interleukin-8, interleukin-15, and chemokine (C-X-C motif) ligand 1 (CXCL1) also promote the proliferation and metastasis of tumor cells (71, 73, 75).