As shown in Table 1, high expression of MPO was strongly associated with a more advanced M stage (P = 0.004), higher pathological stage (P = 0.003), higher CEA level (P = 0.010), more OS death events (P = 0.045), more DSS death events (P = 0.011), and more PFI death events (P = 0.005); in contrast, it was not associated with the T stage, N stage, primary therapy outcome, sex, age, BMI, residual tumor, perineural invasion, lymphatic invasion, history of colon polyps, or colon polyps present (all P > 0.05) (Table 1). Here, MPO is linked to intestinal disorder.