Fourth, for men with initial nadir PSA <1.7 ng/ml after TUEP and progressive PSA elevation to ≥1.7 ng/ml during follow-up, cancer foci or GS ≥7 cancer should be suspected and re-biopsy of the remaining prostate should be considered, which however needs a longer follow-up and more data to confirm. This evidence concerns the gene KLK3 and cancer.