HNF4A and cancer: Upon activation of the WNT pathway, unphosphorylated β-catenin translocates into the nucleus and subsequently triggers TCF/LEF-mediated transcription of downstream genes, such as CCND1, MYC, and CD44. Dysregulation of the WNT/β-catenin signaling pathway is strongly associated with tumorigenesis and progression by maintaining cancer stemness (13).