In addition, the upregulated glycolytic regulator 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) in TAMs is associated with the expression of programmed cell death ligand 1 (PD-L1) to promote immune escape and recurrence of HCC (78). This evidence concerns the gene PFKFB3 and hepatocellular carcinoma.