Moreover, LAYN expression is correlated with diverse immune infiltration levels in cancer, especially in gastric cancer, there is a moderate to strong positive relationships between LAYN expression level and infiltration level of monocyte and M2 macrophages (35), which consistent with our immune assessment results, the high-risk group had higher infiltration levels of monocytes and M2 macrophages compared to the low-risk group. Here, LAYN is linked to gastric cancer.