In the malignant process of CRC, activation of HIF1 can promote tumor growth and glycolysis, and aggravate the damage of the intestinal mucosal barrier.As the degree of hypoxia in the tumor microenvironment deepens, HIF1α will inhibit the transcription of the c-Myc target gene ODC, and the reduction of polyamine synthesis in tumor tissue, the tumor will plunder polyamines from the intestinal mucosa to meet its own energy needs, ultimately leading to intestinal epithelial barrier dysfunction. The gene discussed is HIF1A; the disease is neoplasm.