In line with previous studies that have demonstrated the potential prognostic or predictive value of the dysregulation in the KEAP1-NRF2 pathway in NSCLC patients following chemotherapy and/or radiotherapy (20, 21, 27, 28), our findings independently confirmed its association with poor outcome in NSCLC patients following dCRT. The gene discussed is NFE2L2; the disease is non-small cell lung carcinoma.