(72) recruited four immune-related genes—Serpin Family E Member 1 (SERPINE1), matrix metalloproteinase-12 (MMP12), urokinase type plasminogen activator receptor (PLAUR), and epidermal growth factor receptor kinase substrate 8 (EPS8)—for pCR and outcome prediction of ESCC through a multicenter analysis. Here, SERPINE1 is linked to esophageal squamous cell carcinoma.