In different GBM cells, phytol and retinol show cytotoxic effects at dose dependence, which might be mediated by the levels of SREBP-1, FASN, and farnesyl-diphosphate farnesyltransferase (FDFT1) to downregulate cholesterol and/or fatty acid biosynthetic pathways (154). This evidence concerns the gene SREBF1 and glioblastoma.