In addition, a traditional herbal decoction TJ001 has significant cytotoxicity, induces cell cycle arrest at the G1/S stage, and inhibits lipid accumulation in D145 and PCa cells with p53 mutation by regulating the ACC expression, SREBP-1 proteolytic cleavage, and the inhibition of AMPK/mTOR, which suggest that the combination of mutant p53 targeting and TJ001 can be considered as the potential strategy for PCa treatment (176). This evidence concerns the gene MTOR and posterior cortical atrophy.