An AR degradation enhancer, ASC-J9 suppresses PCa cell growth and invasion by the AR/SREBP-1/FASN pathway in AR-positive cells and PI3K/Akt/SREBP-1/FASN signaling in AR-negative cells, which indicates that it mainly suppresses FASN-mediated PCa progression in both AR-dependent/independent manners (146). The gene discussed is AR; the disease is posterior cortical atrophy.