AKT1 and breast carcinoma: Furthermore, in HER2-overexpressing breast cancer cells, piperineis strongly inhibits proliferation, induces apoptosis, and enhances paclitaxel sensitization through inhibition of SREBP-1/FASN signaling, which might be mediated by HER2 expression, ERK1/2, p38, and Akt signaling pathways (165).