SREBF1 and pancreatic neoplasm: In pancreatic cancer, the CO2 supercritical extract of Yarrow (Achillea millefolium) can downregulate the levels of SREBP-1, FASN, and SCD to induce cytotoxicity in cancer cells and diminish tumor growth of xenograft mouse models, which can be developed as a complementary adjuvant or nutritional supplement (177).