Moreover, the levels of PCK1 pS90, Insig1 pS207/Insig2 pS151, and SREBP-1 are associated with the tumor, metastasis stage, and progression of esophageal squamous cell carcinoma, suggesting PCK1 activity-regulated SREBP-1 as a potential target for the diagnosis and treatment of esophageal cancer (115). The gene discussed is SREBF1; the disease is esophageal cancer.