Collectively, multiple upstream molecules, such as HDGF, AATF, ZHX2, ACSL4, SPIN, HBx, HDAC8, and STAT5, can regulate SREBP-1 expression, activation, and stability to promote HCC proliferation, invasion, and migration for tumor growth and metastasis. The gene discussed is SREBF1; the disease is hepatocellular carcinoma.