SREBF1 and cancer: In gallbladder cancer, α-mangostin, a dietary xanthone, represses the proliferation, clone formation ability, and de novo lipogenesis; induces cell cycle arrest and apoptosis; and enhances gemcitabine sensitivity of gallbladder cancer cells, which might be mediated by AMPK activation and the inhibition of nuclear SREBP-1 translocation in cancer cells and tumor xenograft models (168).