RA-XII, a natural cyclopeptide isolated from Rubia yunnanensis, decreases the motility of HCT 116 cells via inhibition of the β-catenin pathway and inhibits CRC growth and metastasis by downregulating the levels of SREBP-1, FASN, and SCD for restraining lipogenesis (159). The gene discussed is FASN; the disease is colorectal carcinoma.