SREBF1 and skin cancer: In another type of skin cancer, squamous cell carcinomas (SCCs), SREBP-1 can link tumor protein 63 (TP63)/KLF5 to regulate fatty acid metabolism, including fatty acid, sphingolipid, and glycerophospholipid biosynthesis, by binding to hundreds of cis-regulatory elements, which is associated with SCC viability, migration, and poor survival of patients (112).