EGFR and neoplasm: Moreover, several essential pathways, such as epidermal growth factor receptor (EGFR), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB, Akt)/mammalian target of rapamycin (mTOR), and Ras, can regulate SREBP-1 activation to mediate tumor growth and metastasis (15, 16).