In addition, a traditional herbal decoction TJ001 has significant cytotoxicity, induces cell cycle arrest at the G1/S stage, and inhibits lipid accumulation in D145 and PCa cells with p53 mutation by regulating the ACC expression, SREBP-1 proteolytic cleavage, and the inhibition of AMPK/mTOR, which suggest that the combination of mutant p53 targeting and TJ001 can be considered as the potential strategy for PCa treatment (176). Here, SREBF1 is linked to posterior cortical atrophy.