MAPK3 and breast cancer: In breast cancer cells, theanaphthoquinone, a member of the thearubigins generated by the oxidation of theaflavin, can block the EGF-induced nuclear translocation of SREBP-1 and also modulate the phosphorylation of ERK1/2, Akt, and EGFR/ErbB-2 induced by EGF, which can cause the blockade of FASN for the inhibition of cell viability and induction of cell death (164).