SREBF1 and Familial prostate cancer: More importantly, the results from overexpression or RNA interference of SREBP-1c demonstrate that SREBP-1c specifically inhibits AR transactivation by binding to the endogenous AR target promoter, which may be associated with the recruitment of histone deacetylase 1, suggesting that SREBP-1 plays an important role in regulating AR-dependent prostate cancer growth (73).