Several hematological and clinical factors have been shown to suggest a bad prognosis for lung cancer including hypoalbuminemia (16–18); increase of C-reactive protein (18, 19), lactate dehydrogenase (20), PLR (17, 21–23), NLR (17, 21–24), SII (17, 21), and tumor biomarkers (20, 25); abnormal coagulation and fibrinolysis (26, 27); high T and N stage; liver metastasis; adrenal metastasis (28, 29); absence of SMs; smoking history; male; and loss of weight (30). This evidence concerns the gene CRP and Hypoalbuminemia.