NGS covering 51 genes related to hematological malignancies revealed NRAS-p.Gly12Asp, PTPN11-p.Asp61Val, PTPN11-p.Thr468Met, KRAS-p.Gly12Val, and CALR-p.Gly108Arg mutations. This evidence concerns the gene PTPN11 and hematologic disorder.