Next-generation sequencing (NGS) targeting 172 leukemia- and lymphoma-related genes identified ANKRD26-p.Asn267Ser, PTPN11-p.Glu76Lys, CIITA-p.His1119Asn and FAT1-p.Phe765Tyr mutations. The gene discussed is PTPN11; the disease is leukemia.