TP53 and cancer: Whilst the precise mechanism(s) involved in the inverse relationships of TAp63 and ΔNp63 in SCC is uncertain, it will be important to determine whether de-methylation induces TAp63 in all cancers, including tumor types lacking p63 expression but containing mutant p53, where TAp63 may replace p53 activity for therapeutic gain (10, 11, 13), or if TAp63 activation occurs only in cells with an already active TP63 gene.