In this section, we define the overexpressed miR-135a-5p or inhibited TBK1 attenuates inflammation-based responses within mice and LPS-driven ALI, overexpression of miR-135a-5p or inhibition of TBK1 activated NRF2/TXNIP antioxidant pathway and suppresses oxidative stress, and miR-135a-5p negatively regulates TBK1 expression in detail. This evidence concerns the gene TXNIP and acute respiratory distress syndrome.