Their functions are as follows: E1 protein mainly controls virus replication and replication inhibition and is expressed in the early stage of virus infection; E2 protein is a specific DNA binding protein [6], which can not only regulate mRNA transcription and DNA replication but also inhibit the expression of E6 and E7 proteins; E4 protein is expressed during virus infection and plays an important role in virus replication and mutation; E5 protein is the smallest transforming protein [7]. This evidence concerns the gene UBE2B and viral infectious disease.