Although human individuals carrying mutations or deletions of the DDX3Y gene have not been reported, knockout of the DDX3Y gene can also cause reproductive disorders, namely, sertoli cell only syndrome (SCOS), which is characterized by no germ cells in the testis, a low testis volume, and high FSH (Cioppi et al., 2021). Here, DDX3Y is linked to small cell osteogenic sarcoma.