Additionally, several studies have demonstrated an increase in circulating pro-inflammatory factors, such as IL-6, IL-18, and C-reactive protein (CRP) with age, although these correlations become much weaker when underlying cardiovascular disease is taken into account, raising the question of how much these findings are intrinsic to the normal aging process (Ferrucci et al., 2005; Puzianowska-Kuźnicka et al., 2016). The gene discussed is CRP; the disease is cardiovascular disorder.