HNRNPA1 and cancer: For instance, according to Otsuka et al. (Otsuka et al., 2018), by activating the p53 pathway, resveratrol induces the expression of tumor-suppressive miR-34a, miR-424, and miR-503; this, in turn, suppresses the splicing regulator heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), which is associated with oncogenesis and tumor progression and is generally up-regulated in several cancer types in addition to breast cancer, e.g., colorectal cancer, lung cancer, and glioma (Park et al., 2016; Kim et al., 2017).