Indeed, disturbances in one-carbon metabolism (Karmin and Siow, 2018), deregulation of PP2A (Shao et al., 2021) and TJ dysfunction (Denker and Sabath, 2011; Szaszi and Amoozadeh, 2014; Bhat et al., 2018) are all linked to various kidney diseases, including carcinomas. This evidence concerns the gene PTPA and kidney disorder.