↑ Elongation, ↑ remaining in anagen and ↑ Ki67 in HFs. ↑Proliferation, both gene and proteins of ↑β-catenin, ↑Lef-1, ↓BMP2, ↑Shh and ↑GLI1 in ORSCs. This evidence concerns the gene MKI67 and Hand-foot syndrome.