PIK3CA and gastric cancer: Although GSDMB was overexpressed in GC and might act as an oncogene (Saeki et al., 2009), GSDMD was found to be downregulated in GC and could protect against the proliferation of GC through inhibiting S/G2 transition and the STAT3/PI3K/PK8 pathways (Wang et al., 2018).