Thus, glutamine addiction is a hallmark of melanoma (Filipp et al., 2012) that can be triggered by resistance to BRAF inhibitors (Hernandez-Davies et al., 2015; Baenke et al., 2016), and its consumption as an energetic substrate facilitates melanoma cell growth via energy-producing TCA cycle anaplerosis (Ratnikov et al., 2015). Here, BRAF is linked to melanoma.