In addition to its pro-proliferative role that is intimately related with its function as transcriptional regulator of a wide range of metabolic and cell cycle effectors, the MITF locus can be amplified up to 100-times in around 5%–20% of human melanomas (Garraway et al., 2005), supporting its function as lineage-addiction oncogene (Garraway et al., 2005). Here, MITF is linked to melanoma.