Moreover, early in the response to hypoxia, melanoma cells transiently upregulate MITF in a HIF1α-dependent manner, and, interestingly, both co-regulate specific HIF1α targets such as the angiogenic factor VEGF-A and the Sodium/Glucose Cotransporter SLC5A9 (Louphrasitthiphol et al., 2019), in an attempt to mitigate and reverse the effects of hypoxia. The gene discussed is MITF; the disease is melanoma.