Therefore, although targeting mitochondrial oxidative metabolism has been initially considered a good therapeutic strategy to prevent melanoma proliferation (Lim et al., 2014; Luo et al., 2017), on the contrary targeting PGC1α activity may be detrimental for disease progression as low levels of PGC1α can drive melanoma invasiveness and metastasis (Luo et al., 2016). Here, PPARGC1A is linked to melanoma.