More recently, this notion has been corroborated and widened by a series of studies: The proliferative and invasive cell states have been recapitulated by RNA-sequencing analysis of tumor biopsies by Verfaillie et al. (2015), which further highlighted both the role of chromatin remodeling in transcription reprogramming dictating phenotypic plasticity and the absence of correlation with any specific mutation in known melanoma driver genes such as BRAF (Verfaillie et al., 2015). This evidence concerns the gene BRAF and melanoma.