CD36 and cancer: Mechanistically, the presence of exogenous FAs derived from the diet or from adipocytes located in the proximity of the tumor can induce an increase in CD36 needed to promote EMT and metastasis initiation (Nath and Chan, 2016; Pascual et al., 2017; Ladanyi et al., 2018; Yang et al., 2018; Jiang et al., 2019; Pan et al., 2019), and interactions between FA uptake and de-novo FA synthesis might determine the efficacy of targeting CD36 to stop cancer progression (Watt et al., 2019).