However, a limiting aspect may be that the ISR, acutely triggered in melanoma by glucose or glutamine limitation (Falletta et al., 2017; Ferguson et al., 2017), SCD1 inhibition (Vivas-García et al., 2020) and inflammation (Falletta et al., 2017), induces PD-L1 translation and suppresses anti-tumor immunity (Suresh et al., 2020). Here, SCD is linked to melanoma.