The inflammatory hepatic microenvironment, i.e., TNF-α, IFN-γ and oxidative stress induced by KCs and DCs impair the survival and induce the apoptosis of Foxp3+ Treg cells during the apoptosis of hepatocytes and NASH (Ma et al., 2007; Roh et al., 2018). This evidence concerns the gene TNF and metabolic dysfunction-associated steatohepatitis.