The altered expression of enzymes regulating lipid metabolism such as FASN has been proposed to contribute to tumor resistance (Szlasa et al., 2020), and we previously showed that molecular targeting of FASN in melanoma resistant cell lines increased the sensitivity to the BRAFi PLX4032 and resulted in enhanced expression of DHCR24 gene (Stamatakos et al., 2021). The gene discussed is FASN; the disease is neoplasm.