Kilpeläinen et al. characterized homozygous double mutant A30P*A53T α-syn transgenic mice and reported that these animals did show early onset and age-dependent alterations in striatal dopaminergic function and locomotor activity, as well as formation of α-syn oligomers, suggesting that it could be a useful tool for modeling early onset PD associated with familial SNCA mutations (Kilpeläinen et al., 2019). Here, SNCA is linked to Parkinson disease.