Decreased NAD+ and Sirtuin 1 (SIRT1), increased PGC-1α acetylation (inactive form), lower AMPK activity, and overactive mammalian target of rapamycin (mTOR) pathway were also observed in AMD RPE cells, suggesting RPE metabolic dysregulation in AMD (Zhang et al., 2020). The gene discussed is PPARGC1A; the disease is age-related macular degeneration.