The monoclonal antibodies L2 (20/3) blocks the phosphate-mediated current driven by NaPi2b expressed in renal cancer cells SK-RC-18 (Kiyamova et al., 2011) while binding of MX35 mAbs to a largest ECD of NaPi2b inhibits the uptake of inorganic phosphate in HEK293 cells stably expressing WT protein (Gryshkova V. S. et al., 2011). The gene discussed is SLC34A2; the disease is renal carcinoma.