The PI3K-AKT-mTOR signaling pathway, one of the most frequently mutated pathways in human cancer, prevents cancer cells from oxidative stress and ferroptosis through SREBP1/SCD1-mediated adipogenesis during carcinogenic activation (Fruman et al., 2017; Zhang et al., 2017; Zou et al., 2020). The gene discussed is SCD; the disease is cancer.