GPX4 and cancer: SRF@FeIIITA nanoparticles are formed by the self-assembly of iron ions (Fe3+) and tannic acid (TA) on the surface of sorafenib nanocrystals. SRF inhibits GPX4 to induce ferroptosis. The Fe2+ sustainably reduced from TA was toxic to cancer cells. The photosensitizers assist in photodynamic therapy in conjunction with ferroptosis.