TIA1 and amyotrophic lateral sclerosis: Whilst LLPS of TIA-1 contributes to stress granule formation, aberrant LLPS of disease-associated TIA-1 variants and enhanced propensity to form fibrillar aggregates are associated with impaired stress granule dynamics facilitating pathological inclusions linked to ALS (Mackenzie et al., 2017; Zhang et al., 2019).