It was demonstrated that resveratrol-loaded PLGA NPs with sustained-release efficiency reduced the expression of vascular endothelial growth factor (VEGF) in human retinal pigment epithelial (RPE) cells in the treatment of AMD, avoided frequent invasive intravitreal injection, and improved patient compliance (Bhatt, Fnu et al., 2020). The gene discussed is VEGFA; the disease is age-related macular degeneration.