As a result, cell proliferation-associated signaling pathways, such as mitotic spindle, G2M checkpoint, E2F targets, and PI3K/AKT/mTOR signaling, were found to be positively related to senescence in more than 30 cancer types, confirming that senescence is essential for regulating cell-cycle and tumor growth (Figure 9). The gene discussed is AKT1; the disease is cancer.