Furthermore, we found that ETS2, TP53, TFDP2, UBB, CDK6, and ETS1 were hypermethylated in 7, 7, 8, 6, 6, and 7 types of cancer, while E2F2, UBC, CDKN2C, E2F3, E2F1, MAPK1, CDKN2D, TFDP1, CDKN2A, and ERF were hypomethylated in 11, 10, 9, 8, 9, 6, 7, 8, 6 and 6 types of cancer (Figure 8A). The gene discussed is E2F3; the disease is cancer.