The overall methylation levels and the expression of SRGs were negatively correlated, but CDKN2A in GBM, ESCA, MESO, ACC, PCPG, SARC, UCS, and HNSC; CDKN2B in THYM; ID1 in Diffuse large B-cell lymphoma (DLBC); RB1 in STAD and READ; TFDP2 in SKCM; and MAPK1 in TGCT genes’ expression were significantly positively associated with the levels of methylation (Figure 8B; Supplementary Table S6). The gene discussed is RB1; the disease is diffuse large B-cell lymphoma.