RB1 and cancer: Our analysis of the SNV percentage in the gene signatures demonstrated that the top 10 mutated genes were TP53, RB1, CDKN2A, TNRC6A, TNRC6B, TNRC6C, AGO1, MOV10, AGO3, and AGO4, with the mutation frequencies of 78%, 9%, 8%, 6%, 5%, 4%, 3%, 3%, 3%, and 3%, respectively, across TCGA cancer types (Figure 6C).