Therefore, the current study aimed to perform a meta-analysis to quantitatively summarize S100B levels in migraine patients.<h4>Methods</h4>We used Stata 12.0 software to summarize eligible studies from PubMed, EMBASE, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang databases. The gene discussed is S100B; the disease is migraine disorder.