PLA2G6-associated neurodegeneration (PLAN) is a heterogenous group of neurodegenerative diseases caused by mutations of PLA2G6. According to the onset age and clinical features, PLAN can be mainly classified into four subtypes, i.e., infantile onset INAD, childhood onset ANAD, adult-onset DP, and AREP. The gene discussed is PLA2G6; the disease is neurodegenerative disease.