Patients with pathogenic ALG6 variants have abnormal accumulation of Man9GlcNAc2-P-P-Dol and hypoglycosylation of proteins which contribute to autosomal recessive congenital disorder of glycosylation (CDG) Type Ic (or ALG6-CDG) (23, 24). The gene discussed is ALG6; the disease is congenital disorder of glycosylation.