During the course of this study, we became aware of a second consanguineous family of Pakistani origin (Family 2) in which the two affected siblings were found to be also homozygous for the c.785G>A (p.Gly228Arg) variant in CNTNAP2. Clinical presentation in the two affected sisters in Family 2 showed striking overlap with the affected siblings from Family 1, with all four affected individuals exhibiting developmental delay, epilepsy, intellectual disability, and aggressive behaviors (Table 1). The gene discussed is CNTNAP2; the disease is epilepsy.