TARDBP and supranuclear palsy, progressive, 1: In a comparative VBM MRI study of CBS due to four common pathologies of CBD, PSP, AD, and TDP-43, Whitwell et al. (224) found that more widespread cortical atrophy is indicative of an underlying AD or TDP-43 while more focal atrophy of premotor and supplemental motor area is seen with CBD and PSP .