MAPT and supranuclear palsy, progressive, 1: Prior to these reports, a retrospective study of 12 autopsied cases with prominent upper motor neuron as well as extrapyramidal symptoms revealed atypical PSP-like pathological changes, with Gallyas-negative tufted astrocytes and minimal involvement of subcortical nuclei typically involved with PSP, but with significant degeneration of the corticospinal tract due to 4R tau pathology (184).