GRN and Alzheimer disease: Asymmetric presentation of ≥2 cortical + ≥2 movement signs:Cortical signs:• Orobuccal/limb apraxia • Cortical sensory deficit • Alien limb phenomena Movement signs:• Limb rigidity • Limb akinesia • Limb myoclonus Exclusionary criteria:• Positive CSF, PET, or genetic AD biomarkers2• Evidence of: LBD3/MSA4/ALS5/svPPA or nfaPPA • Structural lesion suggestive of focal cause • Granulin mutation or reduced plasma progranulin levels • TDP-43 mutations • FUS mutations ≥1 movement sign + ≥1 cortical sign Meeting no exclusionary criteria